The most effective class of acute migraine medications. Work specifically on migraine pathophysiology, not just pain. Prescription in most countries.

A beta-blocker that is first-line preventive medication for frequent migraines. Typically reduces migraine frequency by 50% in responders.

Regular daily magnesium supplementation has good evidence for reducing migraine frequency as a preventive strategy.

High-dose riboflavin taken daily has consistent evidence for reducing migraine frequency by approximately 50% in responders over 3 months.

Coenzyme Q10 at 300mg/day has shown benefit for migraine prevention in clinical trials. A safe and well-tolerated preventive supplement.

A herb with the best-studied evidence among herbal treatments for migraine prevention. Used for centuries and supported by multiple clinical trials.

A combination of high-dose aspirin and an anti-nausea prokinetic is a guideline-recommended acute treatment for migraine, comparable to sumatriptan in some trials.

Resting in a dark, quiet room with a cold compress on the forehead or neck is the most widely used non-pharmacological approach during an acute migraine.

Systematically tracking potential triggers (sleep changes, foods, stress, hormones, dehydration) and reducing impactful ones can lower attack frequency.