Topical Aciclovir Cream
for Cold Sores
Over-the-counter antiviral cream (5% aciclovir) applied to the cold sore at first sign of tingling, every 4 hours for 5 days.
How it works
Aciclovir is a nucleoside analogue that inhibits HSV-1 DNA polymerase, preventing viral replication and reducing the duration and severity of outbreaks.
What to watch for
Most effective when started at the tingling stage before the blister appears. Will not prevent future outbreaks. Avoid getting in eyes.
Community experience
Anonymous · 0xaf67
1 week ago
Duration of use: Short term
Effectiveness: As expected
Side effects: None
“It great if you feel a cold sore coming on and can sometimes prevent a full outbreak. If it's too far developed it isn't much help and can make the cold sore even more sore.”
Other remedies for Cold Sores
See all 10 remedies →WikiRemedy surfaces community experience, not medical advice. Always consult a qualified health professional.