Low-Dose Naltrexone (LDN)
for Chronic Fatigue
At doses of 1.5–4.5mg (far below the addiction treatment dose), naltrexone modulates the immune system and may reduce the neuroinflammation driving ME/CFS symptoms.
How it works
Transiently blocks opioid receptors, triggering a rebound upregulation of endorphins and reducing microglial activation and neuroinflammation. Mechanism at low doses differs from standard naltrexone.
What to watch for
Requires a prescription and a doctor willing to prescribe off-label — not yet widely available for this indication. Must be compounded at low doses. Avoid if taking opioid medications.
Community experience
Other remedies for Chronic Fatigue
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