Pharma
Low-dose Tricyclic Antidepressants
for IBS / Bloating
At sub-antidepressant doses (e.g. amitriptyline 10–25mg), tricyclics reduce visceral pain perception and normalise gut transit. A well-evidenced second-line option.
How it works
At low doses, TCAs modulate visceral hypersensitivity via central pain processing and slow gut transit, benefiting IBS-D. Mechanism is distinct from their antidepressant action.
What to watch for
Requires a prescription. Constipating effect makes this more appropriate for IBS-D than IBS-C. Side effects include dry mouth and sedation. Do not stop abruptly.
Community experience
Other remedies for IBS / Bloating
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