St. John's Wort for Cessation Mood Support
for Nicotine Withdrawal
St. John's Wort has been investigated as a support for the depression and mood changes that accompany nicotine withdrawal, though evidence for improving quit rates is weak.
How it works
Inhibits reuptake of serotonin, dopamine, and noradrenaline — the same neurotransmitters depleted during nicotine withdrawal. May ease withdrawal-associated low mood.
What to watch for
An RCT found no significant benefit for quit rates specifically. Significant drug interactions — particularly with NRT and bupropion. Consult pharmacist. May be helpful as mood support during the quit if other options are not available.
Community experience
Other remedies for Nicotine Withdrawal
See all 10 remedies →WikiRemedy surfaces community experience, not medical advice. Always consult a qualified health professional.