Tricyclic Antidepressants (Amitriptyline)
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WikiRemedy surfaces community experience, not medical advice. Always consult a qualified health professional.
Time to effect
2–4 weeks
Effort level
low
Category
Pharma
Typical approach
Medication
How it works
Inhibit reuptake of serotonin and noradrenaline in descending pain inhibitory pathways, enhancing the brain's endogenous analgesic system. At low doses (10–75mg), analgesic effects are independent of antidepressant activity.
Prescription only. Low analgesic doses are much lower than antidepressant doses. Side effects include dry mouth, constipation, sedation, and urinary retention — worse in elderly. ECG monitoring if cardiac risk factors present.
Medical guidance
This remedy requires a prescription or pharmacist consultation in Australia. Speak to your GP or pharmacist before use.
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WikiRemedy surfaces community experience, not medical advice. Always consult a qualified health professional.