Pharma
Gabapentin / Pregabalin
for Neuralgia
Gabapentin and pregabalin are widely used for postherpetic neuralgia, diabetic neuropathy, and other neuropathic pain conditions where carbamazepine is poorly tolerated.
How it works
Bind alpha-2-delta subunit of voltage-gated calcium channels in dorsal horn neurons, reducing calcium-dependent neurotransmitter release and decreasing neuropathic pain signalling.
What to watch for
Prescription only. Common side effects: sedation, dizziness, oedema, and cognitive dulling. Risk of dependence with long-term use. Evidence strongest for postherpetic neuralgia and diabetic neuropathy.
Community experience
Other remedies for Neuralgia
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