Low-Dose Naltrexone
for Fibromyalgia
Low-dose naltrexone (LDN, 1.5–4.5mg/day) is an off-label treatment for fibromyalgia with promising evidence for reducing pain via glial cell modulation.
How it works
At low doses, naltrexone transiently blocks opioid receptors, causing a compensatory upregulation of endogenous opioids. Also modulates microglia (CNS immune cells), reducing neuroinflammation thought to contribute to fibromyalgia.
What to watch for
Off-label use — not TGA approved for fibromyalgia. Prescription required. Requires compounding pharmacy for the low dose. Generally well tolerated — vivid dreams in first weeks is the most common side effect. Discuss with GP.
Community experience
Other remedies for Fibromyalgia
See all 10 remedies →WikiRemedy surfaces community experience, not medical advice. Always consult a qualified health professional.