Melatonin
for Migraine
Melatonin supplementation for migraine prevention, particularly in people whose migraines are associated with sleep disruption. Evidence is low certainty. May be worth trialling if sleep issues are a significant contributing factor.
How it works
Melatonin regulates circadian rhythms and may reduce cortical excitability. It also has anti-inflammatory and antioxidant properties. Particularly relevant when migraines are associated with disrupted sleep-wake cycles.
What to watch for
Evidence is low certainty. Not recommended for long-term use without medical supervision. May cause daytime drowsiness. Take 30–60 minutes before sleep. Not established for paediatric migraine without specialist guidance.
Community experience
Other remedies for Migraine
See all 18 remedies →WikiRemedy surfaces community experience, not medical advice. Always consult a qualified health professional.