Natural
Omega-3 Fatty Acids (EPA)
for Depression
High-dose EPA-dominant omega-3 supplementation has evidence as an adjunct treatment for depression, particularly for those with elevated inflammation markers.
How it works
EPA modulates inflammatory cytokines and eicosanoid production. Depression is associated with elevated inflammation in a subset of patients, and omega-3s may address this neuroinflammatory component.
What to watch for
High doses (>3g/day) may increase bleeding risk. Choose EPA-dominant formulas (EPA:DHA ratio ≥2:1). Evidence is strongest as an add-on to antidepressants, not as monotherapy.
Community experience
Other remedies for Depression
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