SSRIs (e.g. sertraline, escitalopram)
for Depression
Selective serotonin reuptake inhibitors (SSRIs) are the most widely prescribed antidepressants. They are recommended for moderate to severe depression and are often used alongside psychological therapy.
How it works
Block reuptake of serotonin in the synaptic cleft, increasing serotonin availability. Downstream effects on neuroplasticity and HPA axis regulation are thought to underlie long-term benefit.
What to watch for
Prescription only. Side effects include nausea, sexual dysfunction, and initial increase in anxiety. Should not be stopped abruptly. Discuss with GP — not appropriate for mild depression.
Community experience
Other remedies for Depression
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