St. John's Wort
NaturalModerate
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WikiRemedy surfaces community experience, not medical advice. Always consult a qualified health professional.
Time to effect
4–6 weeks
Effort level
low
Category
Natural
Typical approach
Supplement / herb
How it works
Active constituents hypericin and hyperforin inhibit reuptake of serotonin, dopamine, and noradrenaline. Flavonoids may also contribute to GABA modulation.
Interacts significantly with many medications including antidepressants, oral contraceptives, anticoagulants, and HIV medications. Not safe to combine with SSRIs — risk of serotonin syndrome. Consult a pharmacist before use.
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WikiRemedy surfaces community experience, not medical advice. Always consult a qualified health professional.