Topical Capsaicin
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Time to effect
Days to weeks (OTC); 8-week effect from single high-dose patch application
Effort level
low
Category
Natural
Typical approach
Supplement / herb
How it works
Capsaicin activates and then desensitises TRPV1 receptors on C-fibre nociceptors, causing depletion of substance P and temporary defunctionalisation of pain fibres in the skin.
OTC low-concentration cream (0.025–0.075%) requires 4–8 weeks of regular application and causes initial burning — warn patients this is expected. High-concentration 8% patch (Qutenza) is clinic-applied and provides ~12-week relief.
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WikiRemedy surfaces community experience, not medical advice. Always consult a qualified health professional.