Topical Capsaicin
for Neuralgia
High-concentration topical capsaicin (8% patch) and low-concentration OTC preparations provide pain relief in peripheral neuropathic pain through desensitisation of cutaneous nociceptors.
How it works
Capsaicin activates and then desensitises TRPV1 receptors on C-fibre nociceptors, causing depletion of substance P and temporary defunctionalisation of pain fibres in the skin.
What to watch for
OTC low-concentration cream (0.025–0.075%) requires 4–8 weeks of regular application and causes initial burning — warn patients this is expected. High-concentration 8% patch (Qutenza) is clinic-applied and provides ~12-week relief.
Community experience
Other remedies for Neuralgia
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